Application of Nanotechnology and Chemical Modeling in Health Delivery: Assessment of Fiber-Influenced Nutrient Absorption Model
This research focused on in-vitro studies of the effect of edible fibers of Phaseolus vulgaris and Citrus sinensis on metal nutrient absorption during digestion in humans. The assessment was initiated by simulating the digestive system. The system was a solid-solution system containing
Cu, chyme, buffer (pH 2.07), and fiber maintained at 310.5 K. By varying time of interaction, chyme volume, the masses of fiber, Zn and Cu independently using batch experiments, the effect of the individual variables on Cu availability was determined. The results revealed that, edible fibers influence metal nutrient availability during digestion in humans in-vitro. In addition, soluble organic compounds participate in the reduction of metal nutrient availability. Nutrient-nutrient competition was observed to occur in the system and leads to the reduction in the availability of one nutrient relative to another. The results suggested that the hypothesis and chemical interaction models developed by Apea and Bisaba may be used to interpret the observed interactions. Finally, it was observed that food-food interaction affect nutrient availability, and understanding the mechanisms and variables involved has the potential to provide information which may be utilized to address nutrition related human health issues.